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Direct T Cell Activation via CD40 Ligand Generates High Avidity CD8(+) T Cells Capable of Breaking Immunological Tolerance for the Control of Tumors
CD40 and CD40 ligand (CD40L) are costimulatory molecules that play a pivotal role in the proinflammatory immune response. Primarily expressed by activated CD4(+) T cells, CD40L binds to CD40 on antigen presenting cells (APCs), thereby inducing APC activation. APCs, in turn, prime cytotoxic T lymphoc...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963987/ https://ncbi.nlm.nih.gov/pubmed/24664420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093162 |
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