Direct T Cell Activation via CD40 Ligand Generates High Avidity CD8(+) T Cells Capable of Breaking Immunological Tolerance for the Control of Tumors

CD40 and CD40 ligand (CD40L) are costimulatory molecules that play a pivotal role in the proinflammatory immune response. Primarily expressed by activated CD4(+) T cells, CD40L binds to CD40 on antigen presenting cells (APCs), thereby inducing APC activation. APCs, in turn, prime cytotoxic T lymphoc...

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Detalhes bibliográficos
Main Authors: Soong, Ruey-Shyang, Song, Liwen, Trieu, Janson, Lee, Sung Yong, He, Liangmei, Tsai, Ya-Chea, Wu, T.-C., Hung, Chien-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963987/
https://ncbi.nlm.nih.gov/pubmed/24664420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093162
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