Toll like receptor agonist imiquimod facilitates antigen-specific CD8+ T cell accumulation in the genital tract leading to tumor control through interferon-γ

PURPOSE: Imiquimod is a toll-like receptor 7 agonist utilized topically to manage genital warts and basal cell carcinoma. We examine the combination of topical imiquimod with intramuscular administration of CRT/E7, a therapeutic HPV vaccination that comprises a naked DNA vector expressing calreticul...

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Detalhes bibliográficos
Main Authors: Soong, Ruey-Shyang, Song, Liwen, Trieu, Janson, Knoff, Jayne, He, Liangmei, Tsai, Ya-Chea, Huh, Warner, Chang, Yung-Nien, Cheng, Wen-Fang, Roden, Richard B.S., Wu, T.-C., Hung, Chien-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216740/
https://ncbi.nlm.nih.gov/pubmed/24893628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0344
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