In Vivo Imaging of mGluR5 Changes during Epileptogenesis Using [(11)C]ABP688 PET in Pilocarpine-Induced Epilepsy Rat Model

INTRODUCTION: Metabotropic glutamate receptor 5 (mGluR5) that regulates glutamatergic neurotransmission contributes to pathophysiology of epilepsy. In this study, we monitored the changes of mGluR5 in vivo using [(11)C]ABP688 PET during the epileptogenesis in a pilocarpine-induced epilepsy rat model...

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Main Authors: Choi, Hongyoon, Kim, Yu Kyeong, Oh, So Won, Im, Hyung-Jun, Hwang, Do Won, Kang, Hyejin, Lee, Boeun, Lee, Yun-Sang, Jeong, Jae Min, Kim, E. Edmund, Chung, June-Key, Lee, Dong Soo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963947/
https://ncbi.nlm.nih.gov/pubmed/24663806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092765
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