Selective Inhibition of Late Sodium Current Suppresses Ventricular Tachycardia and Fibrillation in Intact Rat Hearts

BACKGROUND: Enhanced late inward Na current (I(Na-L)) modulates action potential duration (APD) and plays a key role in the genesis of early and delayed afterdepolarizations (EADs & DADs) and triggered activity. OBJECTIVES: To define the influence of selective block of the I(Na-L) on EAD- &...

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Hlavní autoři: Pezhouman, Arash, Madahian, Sepideh, Stepanyan, Hayk, Ghukasyan, Hayk, Qu, Zhilin, Belardinelli, Luiz, Karagueuzian, Hrayr S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963462/
https://ncbi.nlm.nih.gov/pubmed/24291413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2013.11.026
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