Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion

Phospholemman (PLM), when phosphorylated at Ser(68), inhibits cardiac Na(+)/Ca(2+) exchanger 1 (NCX1) and relieves its inhibition on Na(+)-K(+)-ATPase. We have engineered mice in which expression of the phosphomimetic PLM S68E mutant was induced when dietary doxycycline was removed at 5 wk. At 8–10...

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Main Authors: Wang, JuFang, Song, Jianliang, Gao, Erhe, Zhang, Xue-Qian, Gu, Tongda, Yu, Daohai, Koch, Walter J., Feldman, Arthur M., Cheung, Joseph Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962630/
https://ncbi.nlm.nih.gov/pubmed/24486513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00861.2013
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