Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein

BACE1 (β-secretase) and α-secretase cleave the Alzheimer's amyloid β protein (Aβ) precursor (APP) to C-terminal fragments of 99 aa (CTFβ) and 83 aa (CTFα), respectively, which are further cleaved by γ-secretase to eventually secrete Aβ and Aα (a.k.a. P3) that terminate predominantly at residues...

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Detalhes bibliográficos
Main Authors: Barnwell, Eliza, Padmaraju, Vasudevaraju, Baranello, Robert, Pacheco-Quinto, Javier, Crosson, Craig, Ablonczy, Zsolt, Eckman, Elizabeth, Eckman, Christopher B., Ramakrishnan, Viswanathan, Greig, Nigel H., Pappolla, Miguel A., Sambamurti, Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962361/
https://ncbi.nlm.nih.gov/pubmed/24658363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091531
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