Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP) and cerebrovascular amyloid protein deposits that are defining diagnostic features of Alzheimer’s disease (AD). A number of rare mutations linked to familial AD (FAD) on the Aβ precursor protein (APP), Presenilin...

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Pubblicato in:Curr Alzheimer Res
Autori principali: Baranello, Robert J., Bharani, Krishna L., Padmaraju, Vasudevaraju, Chopra, Nipun, Lahiri, Debomoy K., Greig, Nigel H., Pappolla, Miguel A., Sambamurti, Kumar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820400/
https://ncbi.nlm.nih.gov/pubmed/25523424
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