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Major Carboxyl terminal fragments generated by Gamma-secretase processing of the Alzheimer’s amyloid precursor are 50 and 51 aa in length
OBJECTIVES: To understand the cleavage of the amyloid β protein (Aβ) precursor by γ-secretase and determine its changes in a representative Familial (FAD) Alzheimer’s disease (AD) mutation. METHODS: Transfected cells expressing wild type and FAD mutant APP were analyzed for changes in the levels of...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740189/ https://ncbi.nlm.nih.gov/pubmed/23570890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jagp.2013.02.009 |
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