Targets for AD treatment: conflicting messages from γ-secretase inhibitors

Current evidence suggests that Alzheimer’s disease (AD) is a multi-factorial disease that starts with accumulation of multiple proteins. We have previously proposed that inhibition of γ-secretase may impair membrane recycling causing neurodegeneration starting at synapses (Sambamurti et al., 2006)....

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Main Authors: Sambamurti, Kumar, Greig, Nigel H., Utsuki, Tadanobu, Barnwell, Eliza L., Sharma, Ekta, Mazell, Cheryl, Bhat, Narayan R., Kindy, Mark S., Lahiri, Debomoy K., Pappolla, Miguel A
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076515/
https://ncbi.nlm.nih.gov/pubmed/21320126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07213.x
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