ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here we report that the DNA and p53 binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancre...

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Detalhes bibliográficos
Main Authors: Wang, Lidong, Yang, Huibin, Palmbos, Phillip L., Ney, Gina, Detzler, Taylor Ann, Coleman, Dawn, Leflein, Jacob, Davis, Mary, Zhang, Min, Tang, Wenhua, Hicks, J. Kevin, Helchowski, Corey M., Prasad, Jayendra, Lawrence, Theodore S., Xu, Liang, Yu, Xiaochun, Canman, Christine E., Ljungman, Mats, Simeone, Diane M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961828/
https://ncbi.nlm.nih.gov/pubmed/24469230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2289
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