Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates immune and inflammatory responses, and its overproduction is a hallmark of inflammatory diseases. Inhibition of IL-6 signaling with the anti-IL-6 receptor antibody tocilizumab has provided some clinical benefit to patients; however, direc...

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Detalhes bibliográficos
Main Authors: Gupta, Shashi, Hirota, Masao, Waugh, Sheela M., Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C., Carter, Jeffrey D., Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961692/
https://ncbi.nlm.nih.gov/pubmed/24415766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.532580
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