Missense variant in TREML2 protects against Alzheimer's disease

TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on chromosome 6p21.11. Recent studies have identified a rare coding variant (p.R47H) in TREM2 that confers a high risk for Alzheimer's disease (AD). In addition, common single nucleotide polymorphi...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Benitez, Bruno A., Jin, Sheng Chih, Guerreiro, Rita, Graham, Rob, Lord, Jenny, Harold, Denise, Sims, Rebecca, Lambert, Jean-Charles, Gibbs, J. Raphael, Bras, Jose, Sassi, Celeste, Harari, Oscar, Bertelsen, Sarah, Lupton, Michelle K., Powell, John, Bellenguez, Celine, Brown, Kristelle, Medway, Christopher, Haddick, Patrick CG., van der Brug, Marcel P., Bhangale, Tushar, Ortmann, Ward, Behrens, Tim, Mayeux, Richard, Pericak-Vance, Margaret A., Farrer, Lindsay A., Schellenberg, Gerard D., Haines, Jonathan L., Turton, Jim, Braae, Anne, Barber, Imelda, Fagan, Anne M., Holtzman, David M., Morris, John C., Williams, Julie, Kauwe, John S.K., Amouyel, Philippe, Morgan, Kevin, Singleton, Andy, Hardy, John, Goate, Alison M., Cruchaga, Carlos
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2014
Gaiak:
Genetic Report Abstract
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961557/
https://ncbi.nlm.nih.gov/pubmed/24439484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.12.010
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