Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

The cerebral deposition of Aβ(42), a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer’s disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Sassi, Celeste, Ridge, Perry G., Nalls, Michael A., Gibbs, Raphael, Ding, Jinhui, Lupton, Michelle K., Troakes, Claire, Lunnon, Katie, Al-Sarraj, Safa, Brown, Kristelle S., Medway, Christopher, Lord, Jenny, Turton, James, Morgan, Kevin, Powell, John F., Kauwe, John S., Cruchaga, Carlos, Bras, Jose, Goate, Alison M., Singleton, Andrew B., Guerreiro, Rita, Hardy, John
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889076/
https://ncbi.nlm.nih.gov/pubmed/27249223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150079
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