Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

The cerebral deposition of Aβ(42), a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer’s disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sassi, Celeste, Ridge, Perry G., Nalls, Michael A., Gibbs, Raphael, Ding, Jinhui, Lupton, Michelle K., Troakes, Claire, Lunnon, Katie, Al-Sarraj, Safa, Brown, Kristelle S., Medway, Christopher, Lord, Jenny, Turton, James, Morgan, Kevin, Powell, John F., Kauwe, John S., Cruchaga, Carlos, Bras, Jose, Goate, Alison M., Singleton, Andrew B., Guerreiro, Rita, Hardy, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889076/
https://ncbi.nlm.nih.gov/pubmed/27249223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150079
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