Hsp90 inhibition protects against inherited retinal degeneration

The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple indications in cancer. Hsp90 inhibition activates the heat shock response and can improve viability in a cell model of the P23H misfolding mutation in...

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Autores principales: Aguilà, Mònica, Bevilacqua, Dalila, McCulley, Caroline, Schwarz, Nele, Athanasiou, Dimitra, Kanuga, Naheed, Novoselov, Sergey S., Lange, Clemens A.K., Ali, Robin R., Bainbridge, James W., Gias, Carlos, Coffey, Peter J., Garriga, Pere, Cheetham, Michael E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959821/
https://ncbi.nlm.nih.gov/pubmed/24301679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt613
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