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Hsp90 inhibition protects against inherited retinal degeneration
The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple indications in cancer. Hsp90 inhibition activates the heat shock response and can improve viability in a cell model of the P23H misfolding mutation in...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3959821/ https://ncbi.nlm.nih.gov/pubmed/24301679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt613 |
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