Hsp90 inhibition protects against inherited retinal degeneration

The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple indications in cancer. Hsp90 inhibition activates the heat shock response and can improve viability in a cell model of the P23H misfolding mutation in...

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Bibliographische Detailangaben
Hauptverfasser: Aguilà, Mònica, Bevilacqua, Dalila, McCulley, Caroline, Schwarz, Nele, Athanasiou, Dimitra, Kanuga, Naheed, Novoselov, Sergey S., Lange, Clemens A.K., Ali, Robin R., Bainbridge, James W., Gias, Carlos, Coffey, Peter J., Garriga, Pere, Cheetham, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959821/
https://ncbi.nlm.nih.gov/pubmed/24301679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt613
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