Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) regulatory T cell formation

We have analyzed the relationship between CD4(+)CD8(−) (CD4SP) thymocyte deletion and CD4SPFoxp3(+) Treg formation using mice in which signals transmitted by the TCR have been attenuated by mutation of one of three tyrosine residues (Y145) of the adapter protein Src homology 2 domain-containing leuk...

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Detalhes bibliográficos
Main Authors: Caton, Andrew J., Kropf, Elizabeth, Simons, Donald M., Aitken, Malinda, Weissler, Katherine A., Jordan, Martha S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959276/
https://ncbi.nlm.nih.gov/pubmed/24307208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343767
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