Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants

More than 90 point mutations in human CuZn superoxide dismutase lead to the development of familial amyotrophic lateral sclerosis, known also as motor neuron disease. A growing body of evidence suggests that a subset of mutations located close to the dimeric interface can lead to a major destabiliza...

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Bibliografiska uppgifter
Huvudupphovsmän: Hough, Michael A., Grossmann, J. Günter, Antonyuk, Svetlana V., Strange, Richard W., Doucette, Peter A., Rodriguez, Jorge A., Whitson, Lisa J., Hart, P. John, Hayward, Lawrence J., Valentine, Joan Selverstone, Hasnain, S. Samar
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC395908/
https://ncbi.nlm.nih.gov/pubmed/15056757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305143101
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