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Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants
More than 90 point mutations in human CuZn superoxide dismutase lead to the development of familial amyotrophic lateral sclerosis, known also as motor neuron disease. A growing body of evidence suggests that a subset of mutations located close to the dimeric interface can lead to a major destabiliza...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395908/ https://ncbi.nlm.nih.gov/pubmed/15056757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305143101 |
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