Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis

The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and hydrogen-deuterium (H/D) exchange followed by MS. Contrary to recent reports from other laboratories, we fou...

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Hlavní autoři: Rodriguez, Jorge A., Shaw, Bryan Francis, Durazo, Armando, Sohn, Se Hui, Doucette, Peter A., Nersissian, Aram M., Faull, Kym F., Eggers, Daryl K., Tiwari, Ashutosh, Hayward, Lawrence J., Valentine, Joan Selverstone
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175580/
https://ncbi.nlm.nih.gov/pubmed/16020530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502515102
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