Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

Familial amyotrophic lateral sclerosis (fALS) caused by mutations in copper–zinc superoxide dismutase (SOD1) is characterized by the presence of SOD1-rich inclusions in spinal cords. Similar inclusions observed in fALS transgenic mice have a fibrillar appearance suggestive of amyloid structure. Meta...

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Bibliographic Details
Main Authors: Chattopadhyay, Madhuri, Durazo, Armando, Sohn, Se Hui, Strong, Cynthia D., Gralla, Edith B., Whitelegge, Julian P., Valentine, Joan Selverstone
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Feature Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585484/
https://ncbi.nlm.nih.gov/pubmed/19022905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807058105
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