Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: A possible general mechanism for familial ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder selectively affecting motor neurons; 90% of the total cases are sporadic, but 2% are associated with mutations in the gene coding for the antioxidant enzyme copper–zinc superoxide dismutase (SOD1). The causes of motor ne...

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Autors principals: Banci, Lucia, Bertini, Ivano, Durazo, Armando, Girotto, Stefania, Gralla, Edith Butler, Martinelli, Manuele, Valentine, Joan Selverstone, Vieru, Miguela, Whitelegge, Julian P.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899188/
https://ncbi.nlm.nih.gov/pubmed/17592131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704307104
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