The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation

Aggregation of copper-zinc superoxide dismutase (SOD1) is a defining feature of familial ALS caused by inherited mutations in the sod1 gene, and misfolded and aggregated forms of wild-type SOD1 are found in both sporadic and familial ALS cases. Mature SOD1 owes its exceptional stability to a number...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Chattopadhyay, Madhuri, Nwadibia, Ekeoma, Strong, Cynthia D., Gralla, Edith Butler, Valentine, Joan Selverstone, Whitelegge, Julian P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683282/
https://ncbi.nlm.nih.gov/pubmed/26511321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666503
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