Fitness and Virulence of a Coxsackievirus Mutant That Can Circumnavigate the Need for Phosphatidylinositol 4-Kinase Class III Beta

Coxsackieviruses require phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) for replication but can bypass this need by an H(57)Y mutation in protein 3A (3A-H(57)Y). We show that mutant coxsackievirus is not outcompeted by wild-type virus during 10 passages in vitro. In mice, the mutant virus proved as v...

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Auteurs principaux: Thibaut, Hendrik Jan, van der Schaar, Hilde M., Lanke, Kjerstin H. W., Verbeken, Erik, Andrews, Martin, Leyssen, Pieter, Neyts, Johan, van Kuppeveld, Frank J. M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Genetic Diversity and Evolution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958056/
https://ncbi.nlm.nih.gov/pubmed/24371067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03177-13
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