Fitness and Virulence of a Coxsackievirus Mutant That Can Circumnavigate the Need for Phosphatidylinositol 4-Kinase Class III Beta

Coxsackieviruses require phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) for replication but can bypass this need by an H(57)Y mutation in protein 3A (3A-H(57)Y). We show that mutant coxsackievirus is not outcompeted by wild-type virus during 10 passages in vitro. In mice, the mutant virus proved as v...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Thibaut, Hendrik Jan, van der Schaar, Hilde M., Lanke, Kjerstin H. W., Verbeken, Erik, Andrews, Martin, Leyssen, Pieter, Neyts, Johan, van Kuppeveld, Frank J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958056/
https://ncbi.nlm.nih.gov/pubmed/24371067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03177-13
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados