GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

The replication of enteroviruses is sensitive to brefeldin A (BFA), an inhibitor of endoplasmic reticulum-to-Golgi network transport that blocks activation of guanine exchange factors (GEFs) of the Arf GTPases. Mammalian cells contain three BFA-sensitive Arf GEFs: GBF1, BIG1, and BIG2. Here, we show...

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Bibliographische Detailangaben
Hauptverfasser: Lanke, Kjerstin H. W., van der Schaar, Hilde M., Belov, George A., Feng, Qian, Duijsings, Daniël, Jackson, Catherine L., Ehrenfeld, Ellie, van Kuppeveld, Frank J. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772713/
https://ncbi.nlm.nih.gov/pubmed/19740986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01244-09
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