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Thrombin Down-Regulates the TGF-β-Mediated Synthesis of Collagen and Fibronectin by Human Proximal Tubule Epithelial Cells Through the EPCR-Dependent Activation of PAR-1
Human proximal tubule (HK-2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF-β, extracellular matrix (ECM) proteins and proinflammatory cytokines by HK-2 cel...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3957190/ https://ncbi.nlm.nih.gov/pubmed/20506163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22249 |
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