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Thrombin Up-regulates the Angiopoietin/Tie2 Axis: EPCR occupancy prevents the thrombin mobilization of angiopoietin2 and P-selectin from Weibel-Palade bodies
BACKGROUND: Activated protein C in complex with endothelial protein C receptor (EPCR) can reverse barrier disruptive and cytotoxic effects of proinflammatory cytokines by cleaving protease-activated receptor 1 (PAR-1). Recently, it was reported that the PAR-1-dependent vascular barrier-protective ef...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2891946/ https://ncbi.nlm.nih.gov/pubmed/20180904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2010.03812.x |
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