Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin

Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively. It has been...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Roy, Ram Vinod, Ardeshirylajimi, Abdolreza, Dinarvand, Peyman, Yang, Likui, Rezaie, Alireza R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Vascular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054700/
https://ncbi.nlm.nih.gov/pubmed/27561318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-720581
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