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Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-α-activated endothelial cells by EPCR and PAR-1 dependent mechanisms
INTRODUCTION: Thrombin and tumor necrosis factor (TNF)-α up-regulate the expression of proinflammatory molecules in human umbilical vein endothelial cells (HUVECs). However, activated protein C (APC) down-regulates the expression of the same molecules. The expression level of secretory group IIA pho...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826497/ https://ncbi.nlm.nih.gov/pubmed/19683795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2009.07.015 |
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