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Concentration dependent dual effect of thrombin in endothelial cells via PAR-1 and PI3 kinase
Disruption of endothelial barrier is a critical pathophysiological factor in inflammation. Thrombin exerts a variety of cellular effects including inflammation and apoptosis through activation of the protease activated receptors (PARs). The activation of PAR-1 by thrombin is known to have a bimodal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2663600/ https://ncbi.nlm.nih.gov/pubmed/19189342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21718 |
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