Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke – induced pulmonary injury and emphysema

Rtp801, a stress – related protein triggered by adverse environmental conditions, inhibits mTOR and enhances oxidative stress – dependent cell death. We postulated that Rtp801 acts as potential amplifying switch in the development of cigarette smoke – induced lung injury, leading to emphysema. Rtp80...

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Bibliografiske detaljer
Main Authors: Yoshida, Toshinori, Mett, Igor, Bhunia, Anil K., Bowman, Joel, Perez, Mario, Zhang, Li, Gandjeva, Aneta, Zhen, Lijie, Chukwueke, Ugonma, Mao, Thianzi, Richter, Amy, Brown, Emile, Ashush, Hagit, Notkin, Natalie, Gelfand, Anna, Thimmulappa, Rajesh K, Rangasamy, Tirumalai, Sussman, Thomas, Cosgrove, Gregory, Mouded, Majd, Shapiro, Steven D, Petrache, Irina, Biswal, Shyam, Feinstein, Elena, Tuder, Rubin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956129/
https://ncbi.nlm.nih.gov/pubmed/20473305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2157
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