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MK-2206 Causes Growth Suppression and Reduces Neuroendocrine Tumor Marker Production in Medullary Thyroid Cancer through Akt Inhibition
BACKGROUND: Development of targeted therapies for medullary thyroid cancer (MTC) has focused on inhibition of the RET (Rearranged during Transfection) proto-oncogene. Akt has been shown to be a downstream target of RET via the key mediator phosphoinositide-3-kinase. MK-2206 is an orally administered...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3955957/ https://ncbi.nlm.nih.gov/pubmed/23900743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-013-3168-2 |
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