Inhibition of the AKT pathway in cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis

INTRODUCTION: Cholangiocarcinoma (CCA) is an aggressive disease with limited effective treatment options. The PI3K/Akt/mTOR pathway represents an attractive therapeutic target due to its frequent dysregulation in CCA. MK2206, an allosteric Akt inhibitor, has been shown to reduce cellular proliferati...

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Veröffentlicht in:Cancer Cell Int
Hauptverfasser: Wilson, Jacob M, Kunnimalaiyaan, Selvi, Kunnimalaiyaan, Muthusamy, Gamblin, T Clark
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324843/
https://ncbi.nlm.nih.gov/pubmed/25674039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-015-0161-9
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