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Neuroendocrine phenotypic alteration and growth suppression through apoptosis by MK-2206, an allosteric AKT inhibitor, in carcinoids

Carcinoids are neuroendocrine malignancies, often characterized by their potential to hypersecrete bioactive hormones that contribute to the carcinoid syndrome. Previously, we reported that AKT serves as a central regulator of carcinoid growth and phenotypic expression, demonstrated by genetic silen...

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Main Authors: Somnay, Yash, Simon, Kevin, Harrison, April D., Kunnimalaiyaan, Selvi, Chen, Herbert, Kunnimalaiyaan, Muthusamy
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510354/
https://ncbi.nlm.nih.gov/pubmed/23147412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0b013e3283584f75
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