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Inhibition of Phosphatidylinositol 3-Kinase/Akt Signaling Suppresses Tumor Cell Proliferation and Neuroendocrine Marker Expression in GI Carcinoid Tumors

BACKGROUND: Over-activation of PI3K/Akt signaling facilitates tumor proliferation in several cancers. We have shown that various signal transduction pathways promote tumorigenesis in carcinoid tumors, which exhibit endogenously high levels of active, phosphorylated Akt. Therefore, we hypothesized th...

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Bibliografiske detaljer
Main Authors: Pitt, Susan C., Chen, Herbert, Kunnimalaiyaan, Muthusamy
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917194/
https://ncbi.nlm.nih.gov/pubmed/19588205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-009-0591-5
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