Rational design of a receptor super-antagonist of human interleukin-6.

Interleukin-6 (IL-6) is a differentiation and growth factor for a variety of cell types and its excessive production plays a major role in the pathogenesis of multiple myeloma and post-menopausal osteoporosis. IL-6, a four-helix bundle cytokine, is believed to interact sequentially with two transmem...

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Detalhes bibliográficos
Main Authors: Savino, R, Ciapponi, L, Lahm, A, Demartis, A, Cabibbo, A, Toniatti, C, Delmastro, P, Altamura, S, Ciliberto, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC395561/
https://ncbi.nlm.nih.gov/pubmed/7813426
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