MEF2B mutations lead to deregulated expression of the BCL6 oncogene in Diffuse Large B cell Lymphoma

The MEF2B gene encodes a transcriptional activator and is found mutated in ∼11% of diffuse large B cell lymphomas (DLBCLs) and ∼12% of follicular lymphomas. Here, we show that MEF2B directly activates the transcription of the proto-oncogene BCL6 in normal germinal-center B cells and is required for...

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Hlavní autoři: Ying, Carol Y., Dominguez-Sola, David, Fabi, Melissa, Lorenz, Ivo C., Hussein, Shafinaz, Bansal, Mukesh, Califano, Andrea, Pasqualucci, Laura, Basso, Katia, Dalla-Favera, Riccardo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954820/
https://ncbi.nlm.nih.gov/pubmed/23974956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2688
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