MEF2B instructs germinal center development and acts as an oncogene in B cell lymphomagenesis

SUMMARY: The gene encoding the MEF2B transcription factor is mutated in germinal-center (GC)-derived B-cell lymphomas, but its role in GC development and lymphomagenesis is unknown. We demonstrate that Mef2b deletion reduces GC formation in mice and identify MEF2B transcriptional targets in GC, with...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Brescia, Paola, Schneider, Christof, Holmes, Antony B., Shen, Qiong, Hussein, Shafinaz, Pasqualucci, Laura, Basso, Katia, Dalla-Favera, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223119/
https://ncbi.nlm.nih.gov/pubmed/30205047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.08.006
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