Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventro...

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Main Authors: Ahmari, Susanne E., Spellman, Timothy, Douglass, Neria L., Kheirbek, Mazen A., Simpson, H. Blair, Deisseroth, Karl, Gordon, Joshua A., Hen, René
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954809/
https://ncbi.nlm.nih.gov/pubmed/23744948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234733
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