Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice

Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD, though the underlying pathogenic mechanisms are unknow...

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Autors principals: Welch, Jeffrey M., Lu, Jing, Rodriguiz, Ramona M., Trotta, Nicholas C., Peca, Joao, Ding, Jin-Dong, Feliciano, Catia, Chen, Meng, Adams, J. Paige, Luo, Jianhong, Dudek, Serena M., Weinberg, Richard J., Calakos, Nicole, Wetsel, William C., Feng, Guoping
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442572/
https://ncbi.nlm.nih.gov/pubmed/17713528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06104
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