Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ahmari, Susanne E., Spellman, Timothy, Douglass, Neria L., Kheirbek, Mazen A., Simpson, H. Blair, Deisseroth, Karl, Gordon, Joshua A., Hen, René
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954809/
https://ncbi.nlm.nih.gov/pubmed/23744948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234733
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