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Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3954809/ https://ncbi.nlm.nih.gov/pubmed/23744948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234733 |
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