Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventro...

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Autors principals: Ahmari, Susanne E., Spellman, Timothy, Douglass, Neria L., Kheirbek, Mazen A., Simpson, H. Blair, Deisseroth, Karl, Gordon, Joshua A., Hen, René
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954809/
https://ncbi.nlm.nih.gov/pubmed/23744948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234733
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