BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

The B cell-specific transcription factor BACH2 is required for affinity maturation of mature B cells. Here, we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin V(H)-DJ(H) gene segments. Upon productiv...

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Hlavní autoři: Swaminathan, Srividya, Huang, Chuanxin, Geng, Huimin, Chen, Zhengshan, Harvey, Richard, Kang, Huining, Ng, Carina, Titz, Björn, Hurtz, Christian, Sadiyah, Mohammed Firas, Nowak, Daniel, Thoennissen, Gabriela B., Rand, Vikki, Graeber, Thomas G., Koeffler, H. Phillip, Carroll, William L, Willman, Cheryl L, Hall, Andrew G., Igarashi, Kazuhiko, Melnick, Ari, Müschen, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954721/
https://ncbi.nlm.nih.gov/pubmed/23852341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3247
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