Bach1 Deficiency and Accompanying Overexpression of Heme Oxygenase-1 Do Not Influence Aging or Tumorigenesis in Mice

Oxidative stress contributes to both aging and tumorigenesis. The transcription factor Bach1, a regulator of oxidative stress response, augments oxidative stress by repressing the expression of heme oxygenase-1 (HO-1) gene (Hmox1) and suppresses oxidative stress-induced cellular senescence by restri...

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Autores principales: Ota, Kazushige, Brydun, Andrey, Itoh-Nakadai, Ari, Sun, Jiying, Igarashi, Kazuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094857/
https://ncbi.nlm.nih.gov/pubmed/25050144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/757901
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