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Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

The requirement for a functional retinoblastoma gene, Rb-1, in murine development around days 12-15 of gestation precludes monitoring the effect of loss of Rb-1 function on later stages of development and on tumorigenesis in adult mice. Here we describe the developmental rescue of embryonic stem cel...

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Main Authors: Maandag, E C, van der Valk, M, Vlaar, M, Feltkamp, C, O'Brien, J, van Roon, M, van der Lugt, N, Berns, A, te Riele, H
格式: Artigo
語言:Inglês
出版: 1994
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC395353/
https://ncbi.nlm.nih.gov/pubmed/7925271
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