Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130. To test this hypothesis, we have generated chimeric mice from embryonic...

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Detalhes bibliográficos
Main Authors: Dannenberg, Jan-Hermen, Schuijff, Leontine, Dekker, Marleen, van der Valk, Martin, Riele, Hein te
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC534655/
https://ncbi.nlm.nih.gov/pubmed/15574596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.322004
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