Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130
The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130. To test this hypothesis, we have generated chimeric mice from embryonic...
Gespeichert in:
| Veröffentlicht in: | Genes Dev |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2004
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15574596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.322004 |
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