Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity

ARTEMIS is a member of the metallo-β-lactamase protein family. ARTEMIS has endonuclease activity at DNA hairpins and at 5′- and 3′-DNA overhangs of duplex DNA, and this endonucleolytic activity is dependent upon DNA-PKcs. There has been uncertainty about whether ARTEMIS also has 5′-exonuclease activ...

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Bibliographic Details
Main Authors: Li, Sicong, Chang, Howard H., Niewolik, Doris, Hedrick, Michael P., Pinkerton, Anthony B., Hassig, Christian A., Schwarz, Klaus, Lieber, Michael R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953294/
https://ncbi.nlm.nih.gov/pubmed/24500713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544874
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